The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram, escitalopram, fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are the first-line treatments for anxiety disorders. Psychotherapy and exercise are essential for people suffering from anxiety. Antihistamines such as hydroxyzine (Atarax Vistaril) are prescribed by certain doctors. They work by